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Gabapentin (brand names include Neurontin, Gralise) is a structural analog of the neurotransmitter gamma-aminobutyric acid (GABA), although it does not directly interact with GABA receptors. Instead, its precise mechanism of action is thought to involve binding to a specific subunit (α2δ) of voltage-gated calcium channels in the brain and spinal cord. This action reduces the release of excitatory neurotransmitters like glutamate, norepinephrine, and substance P, thereby modulating abnormal nerve activity that causes seizures or pain.